Kwon, Yong-Ju; Kim, Won-Suk published the artcile< Protecting Group-Controlled Regioselective Synthesis for Unsymmetrical 3,5-Disubstituted Pyridones>, Related Products of 190788-60-4, the main research area is unsym disubstituted pyridone preparation regioselective; dibromo silyloxypyridine Suzuki Miyaura arylation deprotection.
Protecting group-controlled regioselective functionalization of 3,5-dibromo-2-pyridones has been studied for preparation of unsym. 3,5-disubstituted 2-pyridones. A bulky di-tert-butyl(isobutyl)silyl (BIBS) group was utilized for C5 regioselective arylation in Suzuki-Miyaura reactions. Meanwhile, the p-toluenesulfonyl (Ts) group was used to maximize C3 selective halogen-lithium exchange employing flow chem. Most of the reactions proceeded well, with yields of 76 to 95% and excellent regioselectivity. A one-pot synthesis of unsym. 3,5-diaryl-2-pyridones starting from 3,5-dibromo-2-silyloxypyridine was conducted to demonstrate the practical convenience. Further functionalization onto the remaining bromine group, such as transition metal-catalyzed C-C and C-N bond-forming reactions and retro-Brook rearrangement for C-Si bond formation, was accomplished for synthesis of biol. relevant 3,5-disubstituted 2-pyridones. Finally, amrinone and milrinone, commonly used for congestive heart failure, were synthesized in three steps from 3,5-dibromo-2-pyridones in 41% and 56% overall yields, resp.
Advanced Synthesis & Catalysis published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Related Products of 190788-60-4.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem