In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1462-37-9 as follows. Quality Control of ((2-Bromoethoxy)methyl)benzene
Under Ar atmosphere, n-BuLi (1.58M in n-hexane, 0.64mL, 1.00mmol) was added to a solution of 32 (300mg, 0.773mmol) in ether (10mL) at 0¡ãC, and stirred for 1h at room temperature. Then benzyl 2-bromoethyl ether (249mg, 1.16mmol) was added to the mixture and stirred for 18h at room temperature. Then the reaction was quenched with water, and the reaction mixture was diluted with AcOEt. The organic layer was washed with water and brine, dried with Na2SO4 and concentrated. Purification by silica gel column chromatography (eluent; hexane/ethyl acetate, 20:1) gave 265mg (66percent) of 33 as colorless oil. 1H NMR (CDCl3, 400MHz) delta 7.33?7.25 (m, 5H), 4.37 (s, 2H), 3.3?1.3 (br m, 10H), 3.23 (t, J=7.1Hz, 2H), 3.23 (s, 2H), 3.08 (s, 2H), 1.93 (t, J=7.1Hz, 2H), 1.42 (q, J=7.5Hz, 4H), 0.89 (t, J=8.1Hz, 9H), 0.78 (t, J=7.5Hz, 6H), 0.51 (q, J=7.7Hz, 6H).
According to the analysis of related databases, 1462-37-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Fujii, Shinya; Kano, Atsushi; Songkram, Chalermkiat; Masuno, Hiroyuki; Taoda, Yoshiyuki; Kawachi, Emiko; Hirano, Tomoya; Tanatani, Aya; Kagechika, Hiroyuki; Bioorganic and Medicinal Chemistry; vol. 22; 4; (2014); p. 1227 – 1235;,
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