Lu, Biao; Cao, Hu; Cao, Jingsong; Huang, Song; Hu, Qiyue; Liu, Dong; Shen, Ru; Shen, Xiaodong; Tao, Weikang; Wan, Hong; Wang, Dan; Yan, Yinfa; Yang, Liuqing; Zhang, Jiayin; Zhang, Lei; Zhang, Lianshan; Zhang, Minsheng published the artcile< Discovery of EBI-907: A highly potent and orally active B-RafV600E inhibitor for the treatment of melanoma and associated cancers>, Product Details of C8H9BrO2, the main research area is pyrazolo isoquinoline derivative preparation oral BRaf inhibitor cancer structure; B-Raf(V600E); Cancer; Kinase; Pyrazolo[3,4-c]isoquinoline; Scaffold hopping.
A novel series of pyrazolo[3,4-c]isoquinoline derivatives was discovered as B-RafV600E inhibitors through scaffold hopping based on a literature lead PLX4720. Further SAR exploration and optimization led to the discovery of potent B-RafV600E inhibitors with good oral bioavailability in rats and dogs. One of the compounds EBI-907 (13g) demonstrated excellent in vivo efficacy in B-RafV600E dependent Colo-205 tumor xenograft models in mouse and is under preclin. studies for the treatment of melanoma and B-RafV600E associated cancers.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Product Details of C8H9BrO2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem