Jiang, Xiaohuan; Deng, Zhijie; Tang, Pingping published the artcile< Direct Dehydroxytrifluoromethoxylation of Alcohols>, Application In Synthesis of 52244-70-9, the main research area is trifluoromethyl alkyl ether chemoselective preparation; etherification alc trifluoromethyl toluenesulfonate mediated cesium fluoride; dehydroxytrifluoromethylation primary secondary alc trifluoromethyl toluenesulfonate; fluoroformate intermediate dehydroxytrifluoromethylation alc trifluoromethyl toluenesulfonate; alcohols; nucleophilic substitution; synthetic methods; trifluoromethoxylation; trifluoromethyl arylsulfonate.
Primary alcs. and selected secondary alcs. underwent chemoselective direct dehydroxytrifluoromethoxylation with trifluoromethyl p-toluenesulfonate mediated by CsF and tetramethylammonium bromide in HMPA/DMA at 30-100° to yield trifluoromethyl ethers. The trifluoromethylation reaction is operationally simple and scalable, and proceeds under mild reaction conditions to provide access to a wide range of trifluoromethyl ethers from alcs.; functionalized natural products such as a deoxycholic acid-derived triol and pleuromutilin were also used as substrates.
Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem