Yi, Xuewen; Lei, Siyu; Liu, Wangsheng; Che, Fengrui; Yu, Chunzheng; Liu, Xuesong; Wang, Zonghua; Zhou, Xin; Zhang, Yuexia published the artcile< Copper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is copper catalyzed radical demethylation amide fluorobenzenesulfonimide.
An unprecedented N-demethylation of N-Me amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.
Organic Letters published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (N-Me). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem