Zhen, Long; Fan, Hui; Wang, Xiaoji; Jiang, Liqin published the artcile< Synthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using CF3SiMe3 and Elemental Sulfur or AgSCF3 and KBr with Amines>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is thiocarbamoyl fluoride isothiocyanate preparation amine sulfur trifluoromethyl trimethylsilane.
Reactions of thiocarbonyl fluoride derived from cheap, readily available, and widely used CF3SiMe3, elemental sulfur, and KF with secondary amines and primary amines at room temperature in THF provided a wide variety of thiocarbamoyl fluorides and isothiocyanates in moderate to excellent yields, resp. The two reactions show broad substrate scope and good functional group tolerance. Moreover, AgSCF3 reacts with secondary/primary amines under KBr at room temperature, affording quant. thiocarbamoyl fluorides/isothiocyanates, which feature late-stage application.
Organic Letters published new progress about Fluorides Role: SPN (Synthetic Preparation), PREP (Preparation) (thiocarbamoyl). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem