Evindar, Ghotas; Satz, Alexander L.; Bernier, Sylvie G.; Kavarana, Malcolm J.; Doyle, Elisabeth; Lorusso, Jeanine; Taghizadeh, Nazbeh; Halley, Keith; Hutchings, Amy; Kelley, Michael S.; Wright, Albion D.; Saha, Ashis K.; Hannig, Gerhard; Morgan, Barry A.; Westlin, William F. published the artcile< Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists>, Related Products of 52244-70-9, the main research area is amide arylalkoxyphenyl biarylalkoxyphenyl aryloxyphenyl preparation sphingosine phosphate receptor agonist; imidazole arylalkoxyphenyl biarylalkoxyphenyl preparation sphingosine phosphate receptor agonist.
In a search for potent and selective sphingosine-1-phosphate receptor agonists, the previously reported phenylamide and phenylimidazole scaffolds were utilized to explore extensive side-chain modifications to generate new mol. entities. A number of designed mols. demonstrated good selectivity and excellent in vitro and in vivo potency in both mouse and rat models. Oral administration of the lead mol. I (PPI-4667) demonstrated potent and dose-responsive lymphopenia.
Bioorganic & Medicinal Chemistry Letters published new progress about Amides, alkoxylated Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Related Products of 52244-70-9.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem