Adding a certain compound to certain chemical reactions, such as: 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 126-38-5, HPLC of Formula: C5H11BrO2
1-bromo-2,2-dimethoxypropane (1a) (20 g, 109.27 mmol) was dissolved in chloroform (100 mL)Trifluoroacetic acid (74.75 g, 655.59 mmol) was added and reacted at room temperature for 4 hours.The reaction solution was added with dichloromethane (30 mL) and water (150 mL), and the layers were extracted. The organic phase was washed with saturated brine (100 mL x 4), dried over anhydrous sodium sulfate and concentrated at 30 C under reduced pressure to give the title compound Ib as a black oil (11 g, yield 73.5%).
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Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Wei Yonggang; Qiu Guanpeng; Lei Bolin; Li Yao; Wang Song; Zhu Guozhi; (39 pag.)CN106279128; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem