Hernan-Gomez, Alberto; Rodriguez, Monica; Parella, Teodor; Costas, Miquel published the artcile< Electrophilic Iron Catalyst Paired with a Lithium Cation Enables Selective Functionalization of Non-Activated Aliphatic C-H Bonds via Metallocarbene Intermediates>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is diazoester alkyl substituted iron lithium intramol alkylation catalyst; cyclopentane ester stereoselective preparation; C−H activation; carbenes; iron; lithium; reaction mechanisms.
Combining an electrophilic iron complex [Fe(Fpda)(THF)]2 [Fpda=N,N’-bis(pentafluorophenyl)-o-phenylenediamide] with the pre-activation of α-alkyl-substituted α-diazoesters reagents by LiAl(ORF)4 [ORF= OC(CF3)3] provides unprecedented access to selective iron-catalyzed intramol. functionalization of strong alkyl C(sp3)-H bonds. Reactions occur at 25 °C via α-alkyl-metallocarbene intermediates, and with activity/selectivity levels similar to those of rhodium carboxylate catalysts. Mechanistic investigations reveal a crucial role of the lithium cation in the rate-determining formation of the electrophilic iron-carbene intermediate, which then proceeds by concerted insertion into the C-H bond.
Angewandte Chemie, International Edition published new progress about Alkylation catalysts (intramol.). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem