Nie, Xiao-Di; Han, Xiao-Li; Sun, Jian-Ting; Si, Chang-Mei; Wei, Bang-Guo; Lin, Guo-Qiang published the artcile< Nickel-Catalyzed Regioselective Hydroamination of Ynamides with Secondary Amines>, Electric Literature of 10541-78-3, the main research area is ethene diamine preparation regioselective diastereoselective; secondary amine ynamide preparation hydroamination nickel catalyst.
The first Ni(OTf)2-catalyzed hydroamination of ynamides e.g., N-benzyl-4-methyl-N-(2-phenylethynyl)benzene-1-sulfonamide was developed by reacting with secondary amines e.g., N-methylaniline. This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds e.g., I were prepared in moderate to excellent yields with high regioselectivities.
Journal of Organic Chemistry published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (amides). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Electric Literature of 10541-78-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem