Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Product Details of C4H11NO.
Illig, Carl R.;Manthey, Carl L.;Meegalla, Sanath K.;Wall, Mark J.;Chen, Jinsheng;Wilson, Kenneth J.;DesJarlais, Renee L.;Ballentine, Shelley K.;Schubert, Carsten;Crysler, Carl S.;Chen, Yanmin;Molloy, Christopher J.;Chaikin, Margery A.;Donatelli, Robert R.;Yurkow, Edward;Zhou, Zhao;Player, Mark R.;Tomczuk, Bruce E. research published 《 Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors》, the research content is summarized as follows. Structure-activity relationship (SAR) studies on a highly potent series of arylamide FMS inhibitors were carried out with the aim of improving FMS kinase selectivity, particularly over KIT. Potent compound I [R = 4-(HOCH2CH2)piperazin-1-yl] (FMS IC50 0.7 nM, FMS cell IC50 6.1 nM) was discovered that had good PK properties and a greater than fivefold improvement in selectivity for FMS over KIT kinase in a cellular assay relative to the previously reported clin. candidate 4. This improved selectivity was manifested in vivo by no observed decrease in circulating reticulocytes, a measure of bone safety, at the highest studied dose. Compound I [R = 4-(HOCH2CH2)piperazin-1-yl] was highly active in a mouse pharmacodynamic model and demonstrated disease-modifying effects in a dose-dependent manner in a strep cell wall-induced arthritis model of rheumatoid arthritis in rats.
Product Details of C4H11NO, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem