Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Quality Control of 38256-93-8.
Fu, Jiping;Tjandra, Meiliana;Becker, Christopher;Bednarczyk, Dallas;Capparelli, Michael;Elling, Robert;Hanna, Imad;Fujimoto, Roger;Furegati, Markus;Karur, Subramanian;Kasprzyk, Theresa;Knapp, Mark;Leung, Kwan;Li, Xiaolin;Lu, Peichao;Mergo, Wosenu;Miault, Charlotte;Ng, Simon;Parker, David;Peng, Yunshan;Roggo, Silvio;Rivkin, Alexey;Simmons, Robert L.;Wang, Michael;Wiedmann, Brigitte;Weiss, Andrew H.;Xiao, Linda;Xie, Lili;Xu, Wenjian;Yifru, Aregahegn;Yang, Shengtian;Zhou, Bo;Sweeney, Zachary K. research published 《 Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition》, the research content is summarized as follows. Nonimmunosuppressive cyclophilin inhibitors have demonstrated efficacy for the treatment of hepatitis C infection (HCV). However, alisporivir, cyclosporin A, and most other cyclosporins are potent inhibitors of OATP1B1, MRP2, MDR1, and other important drug transporters. Reduction of the side chain hydrophobicity of the P4 residue preserves cyclophilin binding and antiviral potency while decreasing transporter inhibition. Representative inhibitor 33 (NIM258) is a less potent transporter inhibitor relative to previously described cyclosporins, retains anti-HCV activity in cell culture, and has an acceptable pharmacokinetic profile in rats and dogs. An X-ray structure of 33 bound to rat cyclophilin D is reported.
Quality Control of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem