Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Name: Fmoc-Ser-OH.
Ferrer-Gago, Fernando J.;Koh, Li Quan research published 《 Synthesis of C-terminal glycine-rich o-aminoanilide peptides without overacylation for use in benzotriazole-mediated native chemical ligation》, the research content is summarized as follows. Native chem. ligation (NCL) requires the constant development of methods that facilitate the efficient synthesis of C-terminal peptide thioesters, which are key intermediates in NCL. After testing several resins and linkers, we have developed a solid support on the Rink and chlorotrityl chloride resins based on the attachment of o-phenylenediamine (PheDA), with and without an electron withdrawing group. These linkers enable the synthesis of C-terminus o-aminoanilide peptides without overacylation when the glycine is the first amino acid in the synthesis or when we have a glycine-rich sequence. Upon treatment with NaNO2, the glycine o-aminoanilide peptides produce C-terminus benzotriazole (Bt) peptides. The C-terminus-Bt peptides undergo thiol exchange, yielding thioester peptides, which can then be used in an NCL reaction. The linkers attached to the Rink and CT resins efficiently avoid overacylation in the synthesis of glycine-rich sequences, increasing the yield and purity of these sequences.
Name: Fmoc-Ser-OH, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., 73724-45-5.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem