Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Formula: C8H11BO4.
Du, Bingnan;Chan, Chun-Ming;Lee, Pui-Yiu;Cheung, Leong-Hung;Xu, Xin;Lin, Zhenyang;Yu, Wing-Yiu research published 《 2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions》, the research content is summarized as follows. Structurally diverse 2,2-difluorovinyl benzoates (BzO-DFs) RC(O)2C(R1)=C(F2) (R = C6H5, 4-ClC6H4, 1-adamantyl, etc.; R1 = OC2H5, OCH2C6H5, 2-CH3C6H4, etc.) and RC(O)2C(R2)=C(F2) (R2 = 4-(C(CH3)3)C6H4, 2-CH3C6H4, 4-CH3OCC6H4) developed as versatile building blocks for modular synthesis of gem-difluoroenol ethers RC(R1)=C(F2) and R3C(R1)=C(F)2 (R3 = C6H5, 4-ClC6H4, 2-naphthyl, etc.) (44 examples) and gem-difluoroalkenes RC(R1)=C(F2) (R1 = 4-CH3OC6H4, C(CH3)3) (2 examples) by Ni-catalyzed cross coupling reactions have been described. Diverse BzO-DFs derivatives bearing sensitive functional groups (e.g., C = C, TMS, strained carbocycles) are readily prepared from their bromodifluoroacetates R1C(O)C(Br)F2 and bromodifluoroketones precursors using metallic zinc as reductant. With Ni(COD)2 and dppf [1,1′-bis(diphenylphosphino)ferrocene] as catalyst, reactions of BzO-DFs with arylboronic acids R3B(OH)2 and arylmagnesium reagents R2MgBr afforded the desired gem-difluoroenol ethers and gem-difluoroalkenes in good yields. The Ni-catalyzed coupling reactions features highly regioselective C(vinyl)-O(benzoate) bond activation of the BzO-DFs. Results from control experiments and DFT calculations are consistent with a mechanism involving initial oxidative addition of the BzO-DFs by the Ni(0) complex. By virtue of diversity of the BzO-DFs and excellent functional group tolerance, this method is amenable to late-stage functionalization of multifunctionalized bioactive mols.
122775-35-3, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., Formula: C8H11BO4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem