Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Name: Diethylene Glycol Monoethyl Ether.
Echeverry, Sandra M.;Rey, Diana;Valderrama, Ivonne H.;Araujo, Bibiana Verlindo de;Aragon, Diana Marcela research published 《 Development of a self-emulsifying drug delivery system (SEDDS) to improve the hypoglycemic activity of Passiflora ligularis leaves extract》, the research content is summarized as follows. This work aimed to develop, optimize, and evaluate the hypoglycemic activity of P. ligularis leaves extract (PLE) loaded self-emulsifying drug delivery system (SEDDS). The formulation components (oil, surfactant, and co-solvent) were selected based on the solubility studies. A Box-Behnken design (BBD) with 27 treatments was employed to find the optimal composition of PLE-SEDDS, analyzing the droplet size as the response variable. The polydispersity index (PDI) and zeta potential parameters were also measured. The pharmacol. activity was evaluated through a glucose tolerance test. According to ANOVA for the droplet size variable, the linear model was highly significant (p < 0.001), and oil, surfactant, co-solvent, and silicone polymer (PDMSHEPMS) content and their interactions were statistically significant. The final composition of PLE-SEDDS was castor oil, Cremophor EL, propylene glycol, PDMSHEPMS in proportions of 31: 120: 80: 30, resp. The amount of P. ligularis extract incorporated in the formulation was 20%. The final formulation showed a 45.93 ± 1.02 nm droplet size with a PDI 0.27 ± 0.03 and zeta potential -10.92 ± 0.42 mV. Finally, in the in vivo glucose tolerance test, PLE-SEDDS improved hypoglycemic activity compared to the unformulated extract
Name: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem