Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Synthetic Route of 38256-93-8.
Azimioara, Mihai;Alper, Phil;Cow, Christopher;Mutnick, Daniel;Nikulin, Victor;Lelais, Gerald;Mecom, John;McNeill, Matthew;Michellys, Pierre-Yves;Wang, Zhiliang;Reding, Esther;Paliotti, Michael;Li, Jing;Bao, Dingjiu;Zoll, Jocelyn;Kim, Young;Zimmerman, Matthew;Groessl, Todd;Tuntland, Tove;Joseph, Sean B.;McNamara, Peter;Seidel, H. Martin;Epple, Robert research published 《 Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists》, the research content is summarized as follows. Systematic SAR optimization of the GPR119 agonist lead 1, derived from an internal HTS campaign, led to compound 29. Compound 29 displays significantly improved in vitro activity and oral exposure, leading to GLP1 elevation in acutely dosed mice and reduced glucose excursion in an OGTT study in rats at doses ≥10 mg/kg.
38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Synthetic Route of 38256-93-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem