Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Synthetic Route of 530-59-6.
Asif, Muhammad;Zafar, Memoona;Saleem, Mohammad;Saadullah, Malik;Khalid, Syed Haroon;Khan, Shamsuddin Sultan Md;Mahrukh;Iqbal, Zafar;Khan, Ikram Ullah;Hussain, Liaqat;Yaseen, Hafiza Sidra;Zubair, Hafiz Muhammad research published 《 Evaluation of antidiabetic and wound healing properties of ethanol extract of Hedera nepalensis in alloxan-induced diabetic rats》, the research content is summarized as follows. Natural products are known to control diabetes and its associated complications. Leaves of Hedera nepalensis are used to cure diabetes in the folklore system of medicines. The present study was designed to evaluate the in vivo antidiabetic and wound healing potentials of ethanol extract of Hedera nepalensis. Ethanolic extract (Hn.Cr) was prepared by maceration and was chem. characterized by HPLC methods. Antioxidant and antimicrobial properties were assessed in three in vitro models. Toxicity profile of Hn. Cr was evaluated in acute toxicol. studies. Alloxan-induced diabetes model was used to access the antidiabetic attributes of Hn.Cr. Excision wound healing model was used to access the wound healing potential of Hn. Cr in alloxan-induced diabetic rats. HPLC anal. of Hn. Cr revealed the presence of phenolic and flavonoids compounds Data of in vitro antioxidant assays showed that Hn. Cr has moderate radical scavenging potential. In vitro antimicrobial testing results revealed that Hn. Cr was active against bacterial strains (Gram +ve and Gram -ve) while no activity was observed against fungal strains used in the current study. Acute toxicity study results showed that extract was safe up to the dose of 5000 mg/kg. In vivo antidiabetic study revealed that Hn. Cr significantly (p < 0.05) reduced the blood glucose levels in a dose and time-dependent manner. Data of the excisional wound healing model indicated that Hn. Cr accelerated wound healing in diabetic rats in a time-dependent manner. The current study concludes that multicomponent Hn. Cr has antidiabetic and wound healing properties, thus, can be used as a complementary therapy to manage hyperglycemia and wounds in diabetic patients. However, furhter studies are warranted in this regard.
Synthetic Route of 530-59-6, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., 530-59-6.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem