Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Recommanded Product: Diethylene Glycol Monoethyl Ether.
Cardona, Maria I.;Dominguez, Gina P.;Echeverry, Sandra M.;Valderrama, Ivonne H.;Bernkop-Schnurch, Andreas;Aragon, Marcela research published 《 Enhanced oral bioavailability of rutin by a self-emulsifying drug delivery system of an extract of calyces from Physalis peruviana》, the research content is summarized as follows. The aim of this study was to develop and optimize a self-emulsifying drug delivery system (SEDDS) containing an extract of calyces from Physalis peruviana with high mucus permeating properties to increase the bioavailability and the hypoglycemic activity of the active metabolites of the extract The oil, surfactant, and co-solvent were selected based on solubility studies. The formulation was optimized using Box-Behnken statistical exptl. design (BBD). Optimized conditions were Labrafac as oil 10% (weight/weight), Solutol HS 15 as surfactant 45% (weight/weight), propylene glycol as co-solvent 32% (weight/weight) and PDMSHEPMS 13% (weight/weight). The extract was loaded into SEDDS to 45% (weight/weight). The optimized SEDDS exhibited a mean droplet size of 19.5 nm, PDI of 0.20, and neg. zeta potential. Furthermore, SEDDS permeating properties were investigated in porcine intestinal mucus using the Transwell method. Extract-loaded SEDDS showed a 2.6-fold increase in mucus permeation compared to the unformulated extract A pharmacokinetic study showed a nearly 6-fold increase in rutin oral bioavailability in comparison with the unformulated extract Moreover, the hypoglycemic activity of the extract-loaded SEDDS was higher than that of the unformulated extract These results indicate that incorporating an extract of calyces from P. peruviana into SEDDS is a promising strategy to improve the oral bioavailability of the active flavonoids in the extract and the hypoglycemic activity.
Recommanded Product: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem