The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Application of 56621-48-8.Kashif Amir, Muhammad; Hogarth, Graeme; Khan, Zaibunisa; Imran, Muhammad; Zia-ur-Rehman published the article 《Platinum(II) dithiocarbamate complexes [Pt(S2CNR2)Cl(PAr3)] as anticancer and DNA-damaging agents》 about this compound( cas:56621-48-8 ) in Inorganica Chimica Acta. Keywords: platinum dithiocarbamate complex preparation anticancer DNA binding; optimized mol structure platinum dithiocarbamate complex. Let’s learn more about this compound (cas:56621-48-8).
Following the fortunate discovery of cisplatin as an anticancer drug the search for new effective Pt-containing analogs with high potency but reduced side effects and resistance is of great importance. Herein, we report four new monofunctional platinum(II) dithiocarbamate complexes, [Pt(S2CNR2)Cl(PAr3)], and their activity against selected cancer cell lines. DFT-optimized structures reveal steric hindrance, similar to phenanthriplatin, from an axial C-H site of the triarylphosphine. High activity against selected cancer cell lines, MCF-7 > LU > Hepa-IcIc7, can be attributed to the axial protection offered by the aromatic C-H moiety, together with the lipophilicity and formation of bulkier and more hydrophobic DNA adducts. DNA binding, denaturing and plasmid cleavage studies demonstrate their potential to cleave DNA via electrostatic or covalent interactions. DFT and exptl. studies show the ability to replace chloride with different nucleophiles; substitution with smaller nucleophiles being fast while with larger nucleophiles is slow.
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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem