The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Application In Synthesis of 4-(Piperazin-1-yl)phenol.Neves, Gilda; Menegatti, Ricardo; Antonio, Camila B.; Grazziottin, Luiza R.; Vieira, Renan O.; Rates, Stela M. K.; Noel, Francois; Barreiro, Eliezer J.; Fraga, Carlos A. M. published the article 《Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors》 about this compound( cas:56621-48-8 ) in Bioorganic & Medicinal Chemistry. Keywords: heterocyclic phenylpiperazine preparation D2 HT1A receptor ligand antipsychotic. Let’s learn more about this compound (cas:56621-48-8).
The authors described herein the design, synthesis, and pharmacol. evaluation of N-phenylpiperazine heterocyclic derivatives as multi-target compounds potentially useful for the treatment of schizophrenia. The isosteric replacement of the heterocyclic ring at the biaryl motif generating pyrazole, 1,2,3-triazole, and 2-methylimidazole[1,2-a]pyridine derivatives resulted in 21 analogs with different substitutions at the para-biaryl and para-phenylpiperazine positions. Among the compounds prepared, 4 (LASSBio-579) and 10 (LASSBio-664) exhibited an adequate binding profile and a potential for schizophrenia pos. symptoms treatment without cataleptogenic effects. Structural features of this mol. scaffold are discussed regarding binding affinity and selectivity for D2-like, 5-HT1A, and 5-HT2A receptors.
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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem