The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ) is researched.Category: ethers-buliding-blocks.Webster, Lorraine K.; Jones, D. Brian; Mihaly, George W.; Morgan, Denis J.; Smallwood, Richard A. published the article 《Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver》 about this compound( cas:73590-85-9 ) in Biochemical Pharmacology. Keywords: hypoxia omeprazole metabolism liver; oxidation reduction omeprazole liver hypoxia. Let’s learn more about this compound (cas:73590-85-9).
The effect of hypoxia on the elimination of H168-68 (omeprazole)(I) [73590-58-6] a potent inhibitor of gastric acid secretion, was studied in the isolated perfused rat liver. During normal oxygenation, a 10 mg bolus dose was eliminated rapidly (half-life (T1/2)-β = 8.0 min), while under hypoxic conditions T1/2β was increased to 81.6 min. Upon reoxygenation, T1/2β returned to 9.6 min. During hypoxia, perfusate concentrations of an oxidative metabolite (I-sulfone [88546-55-8]) were reduced by 68%, while those of the reductively-generated I-sulfide [73590-85-9] increased 4-fold. With reoxygenation, both formation and elimination of the sulfone were increased, whereas, which had accumulated during the hypoxic period, was eliminated rapidly. These findings were duplicated in steady-state experiments, in which omeprazole clearance during hypoxia fell by at least 70%, and sulfide concentrations in perfusate rose from undetectable levels to 200 ng/mL (at least a 10-fold increase). Sulfone concentrations did not change with hypoxia, consistent with a reduction in both its formation and elimination rates. Thus, the hepatic elimination of omeprazole is severely retarded by hypoxia, but this effect is promptly reversed by reoxygenation. The increased formation of the reductive metabolite during hypoxia is not of sufficient magnitude to sustain the normal hepatic elimination of omeprazole.
In some applications, this compound(73590-85-9)Category: ethers-buliding-blocks is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem