Lagerstroem, Per Olof; Persson, Bengt Arne published the article 《Determination of omeprazole and metabolites in plasma and urine by liquid chromatography》. Keywords: omeprazole metabolite determination blood urine; liquid chromatog omeprazole metabolite.They researched the compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ).Formula: C17H19N3O2S. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:73590-85-9) here.
Omeprazole (I) [73590-58-6], a substituted benzimidazole and a new gastric acid inhibitor, was determined in plasma and urine, together with 3 of its metabolites: the sulfide [73590-85-9], the sulfone [88546-55-8] and the hydroxy compound [92340-57-3]. The methods comprised extraction from the biol. materials with CH2Cl2, followed either by direct injection of the extract onto a normal-phase liquid chromatog. column or evaporation, dissolution, and injection onto a reversed-phase system. The compounds were detected by UV spectrometry. The absolute recoveries obtained were mostly >95%. The min. determinable concentration of omeprazole was 20 nmol/L plasma (relative standard deviation 10-15%) and 50 nmol/L in urine. The metabolites could also be determined at the same levels.
In some applications, this compound(73590-85-9)Formula: C17H19N3O2S is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
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