The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Formula: C10H14N2O.Chen, Peng-Jen; Taylor, Michelle; Griffin, Suzy A.; Amani, Armaghan; Hayatshahi, Hamed; Korzekwa, Kenneth; Ye, Min; Mach, Robert H.; Liu, Jin; Luedtke, Robert R.; Gordon, John C.; Blass, Benjamin E. published the article 《Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands》 about this compound( cas:56621-48-8 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: dopamine receptor G protein coupled receptor drug addiction; D(2); D(3); Dopamine receptor; Drug addiction; G-protein coupled receptor (GPCR). Let’s learn more about this compound (cas:56621-48-8).
As part of our on-going effort to explore the role of dopamine receptors in drug addiction and identify potential novel therapies for this condition, we have a identified a series of N-(4-(4-Ph piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamide D3 ligands. Members of this class are highly selective for D3 vs. D2, and we have identified two compounds (13g and 13r) whose rat in vivo IV pharmacokinetic properties that indicate that they are suitable for assessment in in vivo efficacy models of substance use disorders.
In some applications, this compound(56621-48-8)Formula: C10H14N2O is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem