The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ) is researched.Category: ethers-buliding-blocks.Amantea, Michael A.; Narang, Prem K. published the article 《Improved procedure for quantitation of omeprazole and metabolites using reversed-phase high-performance liquid chromatography》 about this compound( cas:73590-85-9 ) in Journal of Chromatography, Biomedical Applications. Keywords: omeprazole metabolite blood plasma HPLC; liquid chromatog omeprazole metabolite blood. Let’s learn more about this compound (cas:73590-85-9).
An HPLC procedure for the determination of omeprazole and its sulfone and sulfide metabolites in human plasma was developed by using a C8 reversed-phase column with a mobile phase of MeOH-MeCN-0.025M phosphate buffer (40:8:52) adjusted to pH 7.4 with 85% H3PO4 and detection at 302 nm. The level of detection was 5, 10, and 7.5 ng/mL for omeprazole, its sulfone, and the sulfide, resp. and the intraday variability ranged 2.6-10.3 and 2.0-3.5% at 10 and 125 ng/mL, resp. The recoveries were 96, 42, and 96% for omeprazole, the sulfone, and the sulfide, resp.
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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem