The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(Piperazin-1-yl)phenol(SMILESS: OC1=CC=C(N2CCNCC2)C=C1,cas:56621-48-8) is researched.Formula: C17H19N3O2S. The article 《Synthesis of propargylamine mycophenolate analogues and their selective cytotoxic activity towards neuroblastoma SH-SY5Y cell line》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:56621-48-8).
Twenty six propargylamine mycophenolate analogs were designed and synthesized from mycophenolic acid 1 employing a key step A3-coupling reaction. Their cytotoxic activity was examined against six cancer cell lines. Four compounds exhibited selective cytotoxicity towards neuroblastoma (SH-SY5Y) cancer cells and were less toxic to normal cells in comparison to the lead compound, MPA 1 and a standard drug, ellipticine. Mol. docking results suggested that compound I is fit well in the key amino acid of three proteins (CDK9, EGFR, and VEGFR-2) as targets in cancer therapy. The propargylamine mycophenolate scaffold might be a valuable starting point for development of new neuroblastoma anticancer drugs.
This literature about this compound(56621-48-8)Quality Control of 4-(Piperazin-1-yl)phenolhas given us a lot of inspiration, and I hope that the research on this compound(4-(Piperazin-1-yl)phenol) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem