The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.SDS of cas: 56621-48-8.Korzhenko, Kirill S.; Osipov, Dmitry V.; Osyanin, Vitaly A.; Klimochkin, Yuri N. published the article 《Divergent Pathways for Reactions of 3-Formylchromone with Cyclic Secondary Amines in Alcoholic Media》 about this compound( cas:56621-48-8 ) in SynOpen. Keywords: formylchromone cyclic secondary amine methanol diastereoselective Michael reaction; aminomethylene chromanone stereoselective preparation; cyclic secondary amine ring opening formylchromone diastereoselective; hydroxyphenyl aminopropenone preparation. Let’s learn more about this compound (cas:56621-48-8).
Reaction of 3-formylchromone with cyclic secondary amines in methanol results in (E)-chromanones I [X = CH, R = Ph; X = O, R = none; X = N, R = 4-MeC6H4, 2,6-Me2C6H3, 2-MeOC6H4, etc.] and II, while use of ethanol leads to (E)-bis(morpholino)chromanone III or enaminoketones as dihydropyran ring-opening products. The solubility of the formed products in alc. media is postulated to be a key factor that determines the reaction pathway.
In addition to the literature in the link below, there is a lot of literature about this compound(4-(Piperazin-1-yl)phenol)SDS of cas: 56621-48-8, illustrating the importance and wide applicability of this compound(56621-48-8).
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem