So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Patel, Amit B.; Rohit, Jignesh V. researched the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ).Related Products of 56621-48-8.They published the article 《Development of 1,3,4-Thiadiazole and Piperazine Fused Hybrid Quinazoline Derivatives as Dynamic Antimycobacterial Agents》 about this compound( cas:56621-48-8 ) in Polycyclic Aromatic Compounds. Keywords: phenylpiperazinylmethyl thioxodihydrothiadiazolyl phenylquinazolinyloxy benzonitrile antimycobacterial antitumor SAR. We’ll tell you more about this compound (cas:56621-48-8).
Novel series of 1,3,4-thiadiazole and piperazine substituted quinazoline derivatives I [R = H, Cl, CF3, etc] were designed, synthesized, and tested in vitro for antimycobacterial activity. The synthetic procedure involved Suzuki C-C cross-coupling on a quinazoline ring and subsequently by the formation of 1,3,4-thiadiazole based piperazines. Many synthesized analogs were observed active against Mycobacterium H37Rv strain in preliminary anal. using the BACTEC MGIT method. A secondary antimycobacterial assay using the Lowenstein-Jensen MIC method indicates that I [R = bromo, trifluoromethyl, hydroxy] groups substituted analogs was showed strong efficacy in the range of 3.12-6.25 μg/mL. Active compounds were also tested for their cytotoxic activity against Human cervical (HeLa) cells at their MICs. The synthesized analogs were analyzed by IR, 1H NMR, 13 C NMR, MS, and elemental anal. for their structure determination
In addition to the literature in the link below, there is a lot of literature about this compound(4-(Piperazin-1-yl)phenol)Related Products of 56621-48-8, illustrating the importance and wide applicability of this compound(56621-48-8).
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem