The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Quality Control of 4-(Piperazin-1-yl)phenol.Beiginejad, Hadi; Amani, Ameneh; Nematollahi, Davood; Khazalpour, Sadegh published the article 《Thermodynamic study of the electrochemical oxidation of some aminophenol derivatives: Experimental and theoretical investigation》 about this compound( cas:56621-48-8 ) in Electrochimica Acta. Keywords: thermodn electrochem oxidation aminophenol derivative. Let’s learn more about this compound (cas:56621-48-8).
Electrochem. oxidation of some aminophenol derivatives (1-5) was studied both exptl. and theor. Exptl. results were obtained using cyclic voltammetry and controlled potential coulometry. The theor. results were calculated at DFT (B3LYP and BP86) levels of theory and 6-311 + G (p,d) basis sets. Using a general thermodn. cycle, the calculated ΔGtot of the oxidation of the studied aminophenol derivatives indicates that thermodn. is one of the important parameters on the potential oxidation Electrochem. oxidation potential of 1-5 is directly dependent on the ΔGtot of electrochem. oxidation In addition mechanisms of the electrochem. oxidation of 4-(piperazin-1-yl) phenol (6) in the presence of various nucleophiles was studied in viewpoint of the thermodn. Mechanistic study of the electrochem. oxidation of 6 in the presence of different nucleophiles indicates that although the electrochem. oxidations of 6H+ in the presence of different nucleophiles have different mechanisms but proceed in the thermodynamically favored directions.
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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem