The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Simultaneous high-performance liquid chromatographic analysis of omeprazole and its sulfone and sulfide metabolites in human plasma and urine, the main research direction is omeprazole metabolite determination blood urine; liquid chromatog omeprazole metabolite.Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole.
Omeprazole [73590-58-6], a substituted benzimidazole which suppresses gastric acid secretion, and its sulfone [88546-55-8] and sulfide [73590-85-9] metabolites were simultaneously measured in human plasma and urine using a selective, reversed-phase, high-performance liquid chromatog. method with a sensitivity of 5 ng/mL for omeprazole, 30 ng/mL for omeprazole sulfone, and 50 ng/mL for omeprazole sulfide. The coefficients of variation for within-day assays were 4.4, 7.5, and 17.5%, resp. In a pilot pharmacokinetic study, 40 mg of omeprazole (encapsulated enteric-coated granules) were administered to 2 healthy volunteers. Peak plasma concentrations for omeprazole of 240 and 520 ng/mL, and for omeprazole sulfone of 320 and 400 ng/mL, were reached between 3 and 4 post-dose. Omeprazole concentrations fell rapidly with apparent half-lives of about 40 min, and concentrations of both omeprazole and the sulfone metabolite were below the minimal detectable level by 6-8 h. Omeprazole sulfide could not be detected in this study.
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