In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Conformational analysis of 1-arylpiperazines and 4-arylpiperidines, published in 1993-02-28, which mentions a compound: 56621-48-8, mainly applied to conformation piperazine piperidine aryl; AM1 PM3 MNDO arylpiperazine arylpiperidine; mol mechanic arylpiperazine arylpiperidine; rotation barrier arylpiperazine arylpiperidine, Product Details of 56621-48-8.
A conformational anal. of 1-arylpiperazines and 4-arylpiperidines is presented using mol.-mechanics and semi-empirical calculations Electronic effects of substituents on the aryl ring determine the conformational behavior of 1-arylpiperazines. Steric effects play a minor role. Electron-withdrawing substituents on the aryl moiety increase the conjugation between the anilino nitrogen lone pair and the π electrons of the aryl group and direct the orientation between the aryl and heterocycle towards the same plane. Electron-releasing substituents have the opposite effect and reduce the energy difference between a coplanar and perpendicular orientation between the rings. 4-Arylpiperidines prefer a perpendicular orientation between the rings.
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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem