The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Synthesis and characterization of 3-substituted indole derivatives as novel Mannich bases, the main research direction is piperazinyl methyl indole preparation; indole piperazine formalin Mannich microwave irradiation.Safety of 4-(Piperazin-1-yl)phenol.
In this study, indole-based 4-substituted piperazine derivatives I [R = Me, 4-BrC6H4, 4-HOC6H4, 4-F3C6H4, etc.] were synthesized via Mannich reaction with microwave assisted synthesis and the conventional reflux heating method. Microwave assisted synthesis was more preferable than reflux method since the microwave irradiation lead to a higher product yields with better purity and improved energy efficiency with shortened reaction time. The structures of 3-substituted indole derivatives I were characterized by FT-IR, elemental anal., 1H NMR and 13C NMR spectroscopy.
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