Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56621-48-8, is researched, Molecular C10H14N2O, about Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors, the main research direction is itraconazole triazolone synthesis anticancer SAR Hedgehog.Recommanded Product: 56621-48-8.
The Food and Drug Administration-approved antifungal agent, itraconazole (ITZ), has been increasingly studied for its novel biol. properties. In particular, ITZ inhibits the hedgehog (Hh) signaling pathway and has the potential to serve as an anticancer chemotherapeutic against several Hh-dependent malignancies. We have extended our studies on ITZ analogs as Hh pathway inhibitors through the design, synthesis, and evaluation of novel des-triazole ITZ analogs that incorporate modifications to the triazolone/side chain region of the scaffold. Our overall results suggest that the triazolone/side chain region can be replaced with various functionalities (hydrazine carboxamides and meta-substituted amides) resulting in improved potency when compared to ITZ. Our studies also indicate that the stereochem. orientation of the dioxolane ring is important for both potent Hh pathway inhibition and compound stability. Finally, our studies suggest that the ITZ scaffold can be successfully modified in terms of functionality and stereochem. to further improve its anti-Hh potency and physicochem. properties.
When you point to this article, it is believed that you are also very interested in this compound(56621-48-8)Recommanded Product: 56621-48-8 and due to space limitations, I can only present the most important information.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem