Awesome and Easy Science Experiments about 56621-48-8

When you point to this article, it is believed that you are also very interested in this compound(56621-48-8)COA of Formula: C10H14N2O and due to space limitations, I can only present the most important information.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, synthesis, and structure-activity relationship studies of novel pleuromutilin derivatives having a piperazine ring, published in 2016, which mentions a compound: 56621-48-8, Name is 4-(Piperazin-1-yl)phenol, Molecular C10H14N2O, COA of Formula: C10H14N2O.

A series of novel pleuromutilin derivatives I (R = 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 2-HOC6H4, 3-HOC6H4, 4-HOC6H4, 2-NO2C6H4, 3-NO2C6H4, 4-NO2C6H4, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, Ph, Me), possessing piperazine moieties were synthesized under mild conditions. The in vitro antibacterial activities of these derivatives against Staphylococcus aureus and Escherichia coli were tested by the agar dilution method. Structure-activity relationship studies resulted in compounds 11b (R = 3-MeOC6H4), 13b (R = 3-HOC6H4), and 14a (R = 2-NO2C6H4) with the most potent in vitro antibacterial activity among the series (minimal inhibitory concentration of 0.0625-0.125 μg/mL). The binding of compounds 11b, 13b, and 14a to the E. coli ribosome was investigated by mol. modeling, and it was found that there is a reasonable correlation between the binding free energy and the antibacterial activity.

When you point to this article, it is believed that you are also very interested in this compound(56621-48-8)COA of Formula: C10H14N2O and due to space limitations, I can only present the most important information.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem