The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.SDS of cas: 56621-48-8.Staack, Roland F.; Maurer, Hans H. published the article 《Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry》 about this compound( cas:56621-48-8 ) in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. Keywords: forensic methoxyphenyl piperazine metabolism urine GC MS. Let’s learn more about this compound (cas:56621-48-8).
Studies are described on the toxicol. anal. of the piperazine-derived designer drug 1-(4-methoxyphenyl)piperazine (MeOPP) in rat urine using gas chromatog.-mass spectrometry (GC-MS). The authors’ systematic toxicol. anal. (STA) procedure using full-scan GC-MS after acid hydrolysis, liquid-liquid extraction and microwave-assisted acetylation allowed the detection of MeOPP and its metabolites 1-(4-hydroxy phenyl)piperazine and 4-hydroxyaniline in rat urine after administration of a single dose corresponding to doses commonly taken by drug users. Therefore, this procedure should also be suitable for detection of a MeOPP intake in human urine. However, the metabolites of MeOPP are not unique and can be produced from other drugs. Therefore, differentiation of use of this designer drug from use of the medicaments dropropizine, oxypertine or others, which are metabolized to the MeOPP isomer 1-(2-methoxyphenyl)piperazine, is discussed.
As far as I know, this compound(56621-48-8)SDS of cas: 56621-48-8 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem