The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.COA of Formula: C10H14N2O.Al-Soud, Yaseen A.; Alhelal, Kafa’ A. S.; Saeed, Bahjat A.; Abu-Qatouseh, Luay; Al-Suod, Hossam H.; Al-Ahmad, Ala’a H.; Al-Masoudi, Najim A.; Al-Qawasmehe, Raed A. published the article 《Synthesis, anticancer activity and molecular docking studies of new 4-nitroimidazole derivatives》 about this compound( cas:56621-48-8 ) in ARKIVOC (Gainesville, FL, United States). Keywords: nitroimidazolylsulfanyl phenylpiperazinyl propanone preparation antitumor mol docking. Let’s learn more about this compound (cas:56621-48-8).
Herein, we report the synthesis of 3-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-ylsulfanyl)-1-(4-substituted phenyl-piperazin-1-yl)-propan-1-one I [R = H, 2-F, 4-Cl, etc.] by reaction of 3-(1-benzyl-2-methyl-4-nitro-1H-imidazol-5-ylsulfanyl)-propanoyl chloride (3) with piperazine nucleophiles. Eighteen compounds were assessed for their antiproliferative inhibition potency against four human cancer cell lines (MCF-7, PC3, MDA MB231 and Du145). Compounds I [R = 2-Me, 2-OH]were the most potent anticancer agents on MCF-7 cell lines cell line with IC50 value of 1.0μg/mL, while I [R = 2-CN, 4-Cl] exhibited cytotoxic effect on PC3 and DU145 cell lines with IC50 values of 4.0 and 5.0μg/mL, resp. The mol. docking of compounds I [R = 2-Me, 2-CN, 4-Cl] was studied.
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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem