Application of 1663-61-2, A common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, molecular formula is C13H20O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of intermediate 2 (4 g, 15 mmol), acetic anhydride(5.8 g, 56.9 mmol), and triethyl orthobenzoate (10.1 g, 45 mmol)in toluene (25 mL) was stirred for 5 h at 110 C. After that time,the solvent was concentrated. The precipitate was filtered off,and dried to give 3 as a yellow solid (4.56 g, 76percent). 1H NMR(400 MHz, DMSO-d6) d 8.75 (d, J = 1.3 Hz, 1H), 8.11 (d, J = 8.1 Hz,1H), 7.93 (dd, J = 8.1, 1.6 Hz, 1H), 7.61?7.55 (m, 3H), 7.51 (dd,J = 7.7, 1.8 Hz, 2H), 4.86 (s, 2H), 4.03 (m, 2H), 3.89 (s, 3H), 1.36(t, J = 7.0 Hz, 3H). ESI-MS m/z: 400.0 [M+H]+.
The synthetic route of 1663-61-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Qin, Mingze; Yan, Shuang; Wang, Lei; Zhang, Haotian; Tian, Ye; Zhao, Yanfang; Gong, Ping; Bioorganic and Medicinal Chemistry; vol. 25; 6; (2017); p. 1778 – 1786;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem