An article Aerobically-initiated C(sp(3))-H bond amination through the use of activated azodicarboxylates WOS:000560553400007 published article about C-H AMINATION; ACYL HYDRAZIDES; DIETHYL-ETHER; METAL-FREE; HYDROACYLATION; ALDEHYDES; ARENES; GREEN; AUTOXIDATION; CHALLENGES in [Shamsabadi, Andre; Maruani, Antoine; Ahmed, Nehaal; Chudasama, Vijay] UCL, Dept Chem, London, England in 2020, Cited 49. Application In Synthesis of Benzyl ether. The Name is Benzyl ether. Through research, I have a further understanding and discovery of 103-50-4
Significant advancements in C-N bond formationviaC-H bond functionalisation have made it a staple in the production of nitrogen-containing compounds in both industry and academia. However, transition metal-free synthesis, particularly in the case of C(sp(3))-N formation, has remained a significant challenge to the synthetic community. Herein we report a procedure for alpha-C(sp(3))-H amination of ethereal compounds through use of azodicarboxylates as the nitrogen source and freely-available atmospheric oxygen to access ethereal radical intermediatesviaaerobic C-H activation. The use of fluorinated alcohols as solvent is observed to greatly increase the efficiency of the reaction and we show experimentally and theoretically the key role of H-bonding between fluorinated alcohols and azodicarboxylates. Calculations of the condensed Fukui functions of a H-bonded fluorinated alcohol-azodicarboxylate complex correlates with a significantly increased susceptibility of azodicarboxylates to undergo reaction with radicals, which informs a number of recent reports in the literature.
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Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem