Shu, GF; Chen, MJ; Song, JJ; Xu, XL; Lu, CY; Du, YY; Xu, M; Zhao, ZW; Zhu, MX; Fan, K; Fan, XX; Fang, SJ; Tang, BF; Dai, YY; Du, YZ; Ji, JS in [Shu, Gaofeng; Chen, Minjiang; Song, Jingjing; Lu, Chenying; Xu, Min; Zhao, Zhongwei; Fan, Kai; Fan, Xiaoxi; Fang, Shiji; Tang, Bufu; Ji, Jiansong] Zhejiang Univ, Sch Med, Key Lab Imaging Diag & Minimally Invas Intervent, Lishui Hosp, Lishui 323000, Zhejiang, Peoples R China; [Shu, Gaofeng; Xu, Xiaoling; Zhu, Minxia; Du, Yongzhong] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, 866 Yu Hang Tang Rd, Hangzhou 310058, Peoples R China; [Du, Yuyin] Tohoku Univ, Fac Sci, Dept Chem, Sendai, Miyagi 9808577, Japan; [Dai, Yiyang] Zhejiang Univ, Sch Med, Dept Gastroenterol, Affiliated Hosp 4, Yiwu 32200, Peoples R China published Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe3+ as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer in 2021, Cited 58. Name: Benzyl ether. The Name is Benzyl ether. Through research, I have a further understanding and discovery of 103-50-4.
Hepatic cancer is a serious disease with high morbidity and mortality. Theranostic agents with effective diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer. Herein, we aimed to develop a novel mesoporous polydopamine (MPDA)-based theranostic agent for T1/T2 dual magnetic resonance imaging (MRI)-guided cancer chemo-photothermal therapy. Superparamagnetic iron oxide (SPIO)-loaded MPDA NPs (MPDA@SPIO) was firstly prepared, followed by modifying with a targeted molecule of sialic acid (SA) and chelating with Fe3+ (SA-MPDA@SPIO/Fe3+ NPs). After that, doxorubicin (DOX)-loaded SA-MPDA@SPIO/Fe3+ NPs (SA-MPDA@SPIO/DOX/Fe3+) was prepared for tumor theranostics. The prepared SAPEG-MPDA@SPIO/ Fe3+ NPs were water-dispersible and biocompatible as evidenced by MTT assay. In vitro photothermal and relaxivity property suggested that the novel theranostic agent possessed excellent photothermal conversion capability and photostability, with relaxivity of being r(1) = 4.29 mM(-1)s(-1) and r(2) = 105.53 mM(-1)s(-1), respectively. SAPEG-MPDA@SPIO/Fe3+ NPs could effectively encapsulate the DOX, showing dual pH- and thermal-triggered drug release behavior. In vitro and in vivo studies revealed that SA-MPDA@SPIO/DOX/Fe3+ NPs could effectively target to the hepatic tumor tissue, which was possibly due to the specific interaction between SA and the overexpressed E-selectin. This behavior also endowed SA-MPDA@SPIO/DOX/Fe3+ NPs with a more precise T1-T2 dual mode contrast imaging effect than the one without SA modification. In addition, SAPEG-MPDA@SPIO/DOX/Fe3+ NPs displayed a superior therapeutic effect, which was due to its active targeting ability and combined effects of chemotherapy and photothermal therapy. These results demonstrated that SAPEG-MPDA@SPIO/DOX/Fe3+ NPs is an effective targeted nanoplatform for tumor theranostics, having potential value in the effective treatment of hepatic cancer.
Name: Benzyl ether. Welcome to talk about 103-50-4, If you have any questions, you can contact Shu, GF; Chen, MJ; Song, JJ; Xu, XL; Lu, CY; Du, YY; Xu, M; Zhao, ZW; Zhu, MX; Fan, K; Fan, XX; Fang, SJ; Tang, BF; Dai, YY; Du, YZ; Ji, JS or send Email.
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem