An article Heavily superparamagnetic magnetite-loaded polymeric worm-like micelles that have an ultrahighT(2)relaxivity WOS:000575294200003 published article about IRON-OXIDE NANOPARTICLES; MRI CONTRAST AGENTS in [Zou, Yunlong; Li, Yanran; Xu, Jiayin; Huang, Xiayun; Chen, Daoyong] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200438, Peoples R China in 2020, Cited 17. Recommanded Product: 103-50-4. The Name is Benzyl ether. Through research, I have a further understanding and discovery of 103-50-4
Composite worm-like micelles (CWMs) that encapsulate a large number of superparamagnetic magnetite nanoparticles (SMNPs) within the core while still having a small width should have a high magnetic resonance sensitivity and simultaneously a desirable circulation behaviour in biological systems. However, the preparation of such CWMs is still a challenge. Herein we report the fabrication of CWMsviatwo-stage self-assembly of SMNPs guided by a block copolymer and DNA, respectively. First, poly(ethylene glycol)-b-poly(4-vinylpyridine) co-assembled with SMNPs to form spherical composite micelles, guiding the clustering of multiple SMNPs within the core of the micelles. Then, at the second stage, DNA co-assembled with and guided the linear aggregation and fusion of the micelles, resulting in the CWM encapsulating a large number of SMNPs in the linear core. As a proof of concept, CWMs with aT(2)relaxivity as high as 704 mM(-1)s(-1)and a low MRI detection limit of 2.2 mu g mL(-1)(similar to 0.02 nM CWMs) were prepared; it is significant that theT(2)relaxivity of the SMNPs assembled in the CWMs is around 20 times that of the same SMNPs in the same amount but individually dispersed in the suspension. Additionally, although heavily loaded with SMNPs, the CWMs have a width as small as 20.5 nm and a core-shell structure with PEG as the shell. These features should make the CWMs very promising in their use as ultra-sensitive magnetic resonance imaging probes.
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