In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: ethers-buliding-blocks
EXAMPLE 144 3-Chloro-4-hydroxybenzoic Acid {4-[2-(4-Trifluoromethoxy)benzylaminoethoxy]-1-naphthylmethylene}hydrazide To a flask containing 4-trifluoromethoxybenzylamine (0.29 g, 1 mmole) in DMF (5 mL) was added 3-chloro-4-hydroxybenzoic acid [4-(2-chloroethoxy)-1-naphthylmethylene]hydrazide (0.403 g, 1 mmole) and triethylamine (0.1 g, 1mmole). The resulting solution was heated at 80 C. for 16 hours. Removal of most of the solvent in vacuo, followed by flash chromatography (10:1 CHCl3/MeOH) on silica gel provided the title compound as a brown solid. 1H NMR (DMSO-d6): delta 11.6 (s, 1H), 9.0 (m 2H), 8.3 (m 1H), 8.0 (m, 1H), 7.8 (s, 2H), 7.7 (m, 1H), 7.6 (m, 1H), 7.5 (m, 3H), 7.3 (m, 2H), 7.1 (m, 2H), 4.3 (t, 2H), 3.9 (s, 2H), 3.0 (t, 2H). MS (CI): 557, 559.
The synthetic route of 93919-56-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Novo Nordisk A/S; US6613942; (2003); B1;,
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