Adding a certain compound to certain chemical reactions, such as: 1579-40-4, name is Di-p-tolyl Ether, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1579-40-4, Recommanded Product: 1579-40-4
To a stirred mixture of4′, 4′- dimethyldiphenylether (200 g; 1.01 mole), p-methybenzoic acid (154 g; 1.13 mole) and anhydrous zinc chloride (400 g; 2.94 mole) was added phosphorousoxy trichloride (300ml ; 3. 27 mole) slowly using an addition funnel. The reaction mixture was then slowly heated to95 C when the reaction starts and monitored by tlc. After the reaction is complete, ethyl acetate (500 ml) was added, followed by water (200 ml) slowly. An additional amount of water (2500 ml) was added at a faster rate. Stirred overnight at room temperature when solid comes out. It was filtered and recrystallized from methanol to afford the substituted pixyl alcohol product.
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Reference:
Patent; ISIS PHARMACEUTICALS, INC.; WO2005/49621; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem