Related Products of 450-88-4, These common heterocyclic compound, 450-88-4, name is 1-Bromo-4-fluoro-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
15 g of 1-bromo-4-fluoro-2-methoxybenzene obtained by Production example 89 was dissolved in 150 mL of 1-methyl-2-pyrrolidone, added with 9.9 g of copper cyanide (I), and stirred at 180C for 5 hours. After allowing to cool, the reaction solution was poured into 500 mL of 14% ammonia aqueous solution, stirred for 45minutes, then added with 150 mL of diethyl ether, and stirred for another 10 minutes. After filtering off the insoluble substances through Celite, the solution was extracted with diethyl ether. The organic layer was washed with diluted aqueous ammonia, 5N hydrochloric acid, water and saturated brine, and dried over magnesium sulfate. The solvent was evaporated, to afford 10.1 g of the title compound as white crystals.1H-NMR ( 400 MHz, CDCl3 ) delta 3.93 ( 3H, s ), 6.67 – 6.74 ( 2H, m ), 7.54 ( 1H, dd, J = 6.0, 8.4 Hz )
The synthetic route of 450-88-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eisai Co., Ltd.; EP1510516; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem