Synthetic Route of 592-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 592-55-2, name is 1-Bromo-2-ethoxyethane, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a stirred solution of 22 (30 mg, 0.081 mmol) in DMF (3 mL) were added K2CO3 (170 mg, 1.20 mmol), NaI (180 mg, 1.20 mmol) and 2-bromoethyl methyl ether (75 muL, 0.81 mmol), and stirred at 100 C under an Ar atmosphere. After 3 h with stirring, the reaction mixture was evaporated in vacuo. The resulting mixture was basified (pH 9) with saturated NaHCO3 aqueous solution and extracted with CHCl3 three times. The combined organic extracts were washed with brine, dried over Na2SO4, and evaporated in vacuo. The residue was purified by preparative TLC (CHCl3/MeOH = 10:1) to give 26 (27 mg, 77%) as a colorless oil.
The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-ethoxyethane. I believe this compound will play a more active role in future production and life.
Reference:
Article; Nemoto, Toru; Ida, Yoshihiro; Iihara, Yusuke; Nakajima, Ryo; Hirayama, Shigeto; Iwai, Takashi; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7628 – 7647;,
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