Application of 93-04-9, These common heterocyclic compound, 93-04-9, name is 2-Methoxynaphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 1 The following is a procedure for preparing 2-methoxy-6-ethylnaphthalene by the transethylation of 2-methoxynaphthalene. To a 250 ml., 3-neck, round-bottom flask equipped with a magnetic stirrer and a sparge tube were added 70 g of mixed diethylbenzenes obtained from the Aldrich Chemical Company, Milwaukee, Wis. After cooling the reaction mixture with an ice bath, hydrogen chloride gas was added for three minutes and thereupon 14.48 grams of aluminum chloride were slowly added. Hydrogen chloride gas was again added for three minutes. The reaction flask was then placed in a hot water bath to raise the temperature of the reaction mixture to 85-90 C. At this point ethylene gas was sparged into the reaction mixture until the level of tetraethylbenzene in the reaction mixture was maximized. The composition of the mixture was monitored by gas chromatography. After the ethylene addition was stopped, the reaction mixture was stirred for an additional 30 minutes at 90 C. To the above reaction mixture at 15 C. was added a mixture of 29.02 grams of 2-methoxynaphthalene dissolved in 50 ml of dichloromethane. The reaction mixture was permitted to warm to room temperature and after 900 minutes it was heated to 32 C. using a water bath. After 15 hours total reaction time the yield of 2-methoxy-6-ethylnaphthalene was 71.5% as measured by gas chromatography. This example shows the high yield of 2-methoxy-6-ethylnaphthalene that can be achieved by the method of this invention.
Statistics shows that 2-Methoxynaphthalene is playing an increasingly important role. we look forward to future research findings about 93-04-9.
Reference:
Patent; Amoco Corporation; US5235115; (1993); A;,
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