Holmberg-Douglas, N; Onuska, NPR; Nicewicz, DA in [Holmberg-Douglas, Natalie; Onuska, Nicholas P. R.; Nicewicz, David A.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA published Regioselective Arene C-H Alkylation Enabled by Organic Photoredox Catalysis in 2020.0, Cited 29.0. Product Details of 101-84-8. The Name is Diphenyl oxide. Through research, I have a further understanding and discovery of 101-84-8.
Expanding the toolbox of C-H functionalization reactions applicable to the late-stage modification of complex molecules is of interest in medicinal chemistry, wherein the preparation of structural variants of known pharmacophores is a key strategy for drug development. One manifold for the functionalization of aromatic molecules utilizes diazo compounds and a transition-metal catalyst to generate a metallocarbene species, which is capable of direct insertion into an aromatic C-H bond. However, these high-energy intermediates can often require directing groups or a large excess of substrate to achieve efficient and selective reactivity. Herein, we report that arene cation radicals generated by organic photoredox catalysis engage in formal C-H functionalization reactions with diazoacetate derivatives, furnishing sp(2)-sp(3) coupled products with moderate-to-good regioselectivity. In contrast to previous methods utilizing metallocarbene intermediates, this transformation does not proceed via a carbene intermediate, nor does it require the presence of a transition-metal catalyst.
Product Details of 101-84-8. About Diphenyl oxide, If you have any questions, you can contact Holmberg-Douglas, N; Onuska, NPR; Nicewicz, DA or concate me.
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem