14869-41-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14869-41-1 name is 2-(2-Chloroethoxy)acetic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
90 ml toluene, lO.OOg 2-(2-chloroethoxy)acetic acid (X) oily extract obtained from one of the previous examples, 8.3 Ig 4-nitro-aniine and l .84g phenyl -boronic acid are measured into a 125 ml volume sulfonating flask equipped with a Dean-Stark attachment, a condenser and thermometer. The mixture is heated to the reflux temperature (1 10- 1 11 C), the reaction is checked by a TLC method. After the end of the reaction the mixture is cooled back, 1.00 ml ethylene-glycol is added. Then the mixture is heated again to the temperature of reflux, then it is refluxed for another half an hour. Then the mixture is cooled to a temperature of 0-5C. The suspension is filtered and washed with toluene. The filtrate is dried to a constant mass. The mass of the obtained pastel yellow powder: 12.98g, yield: 83%
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Chloroethoxy)acetic acid, and friends who are interested can also refer to it.
Reference:
Patent; RICHTER GEDEON NYRT.; SZABO, Tamas; NEU, Jozsef; GARADNAY, Sandor; (17 pag.)WO2019/138362; (2019); A1;,
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