Reference of 1758-46-9,Some common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution OF 5- (3APOS;-CARBOXY-4-METHOXY-1, 1APOS;-BIPHEN-3-YL)-1, 2,5-thiadiazolidin-3-one 1, 1-dioxide (Example 43) (0.05 g, 0.14 mmol, 1 eq. ) and DIPEA (24 L, 0.14 mmol, 1 eq. ) in DCM (2mL) added HOBt (19 mg, 0.14 mmol, 1 eq. ), 2-phenoxyethylamine (18 RL, 0.14 mmol, 1 eq. ) and EDCI (31 mg, 0.17 mmol, 1.2 eq. ). The reaction was allowed to stir at ambient temperature overnight and then the solvent was removed under reduced pressure. The residue was taken up in acetonitrile: water (1: 1,3 mL) and purified by reverse phase preparative HPLC to afford the title compound as a colourless solid (0.04 g, 60percent yields
The synthetic route of 1758-46-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/41799; (2004); A1;,
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