Some common heterocyclic compound, 36865-41-5, name is 1-Bromo-3-methoxypropane, molecular formula is C4H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: ethers-buliding-blocks
A 250 mL round-bottomed flask was charged with 5-bromo-2-methoxy-phenol ( 1 .5 g, 76.4 mmol), l -bromo-3-methoxy-propane (12.9 g, 84 mmol), K >C( , (22 g, 2 153 mmol) and DM F (50 mL). The resultant mixture was stirred at 50 C for 3 hours, and then ethyl acetate and water was added. The organic phase was separated, and then dried over anhydrous Na?SO.and then concentrated to give 4-bromo- l -methoxy-2-(3-methoxypropoxy)benzene (23 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36865-41-5, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; YANG, Song; HAN, Xingchun; WANG, Zhanguo; (96 pag.)WO2015/173164; (2015); A1;,
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