Reference of 109-85-3,Some common heterocyclic compound, 109-85-3, name is 2-Methoxyethylamine, molecular formula is C3H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 2,3-dichloro-1,4-naphthoquinone (0.341g, 1.50mmol) in 1.5mlof ethanol was added 2-methoxyethylamine (0.124g, 1.65mmol) and triethylamine (0.227g,2.25mmol) and the mixture stirred at r. t. for 18h. The red precipitate formedwas filtered under suction, washed with distilled water and dried to afford (4) as a dark red solid, 87.8%.1H (CDCl3) delta 8.15 (dd, 1H, J=0.94, 7.68Hz), 8.03 (dd, 1H, J=0.99, 7.67Hz), 7.72 (dt, 1H, J=1.31, 7.59Hz), 7.62 (dt, 1H, J=1.28, 7.55Hz), 6.36 (br s, 1H), 4.06(dd, 2H, J=5.60, 10.62Hz), 3.63(t, 2H, J=5.17Hz), 3.42 (s, 3H); 13C(CDCl3) delta 180.42, 176.84, 144.37, 134.85, 132.67, 132.44, 129.88,126.80, 77.20, 71.22, 58.95, 44.50.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxyethylamine, its application will become more common.
Reference:
Article; Ho, Si-Han Sherman; Sim, Mei-Yi; Yee, Wei-Loong Sherman; Yang, Tianming; Yuen, Shyi-Peng John; Go, Mei-Lin; European Journal of Medicinal Chemistry; vol. 104; (2015); p. 42 – 56;,
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