Adding a certain compound to certain chemical reactions, such as: 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2674-34-2, Product Details of 2674-34-2
Reacting a compound of formula 4 with sodium hydride in tetrahydrofuran as a solvent at -78 C for two hours,At the same time, the compound of formula 5 was reacted with n-butyllithium using tetrahydrofuran as a solvent at -78 C for one hour, and then mixed at -78 C for two hours.Add N, N-dimethylformamide and stir for five minutes, add methyl iodide to react at room temperature for twelve hours, add water to quench the reaction,The crude product was subjected to column chromatography with ethyl acetate and petroleum ether system to obtain intermediate formula 6 required for Suzuki Coupling Reaction, with a reaction yield of 52%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; University of the Chinese Academy of Sciences; Cong Huan; Fan Yangyang; (9 pag.)CN110272332; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem